XII International Celiac Disease Symposium 2006

Program
International Symposium

The International Symposium is a scientific program designed for physicians and scientists. Experts will discuss the latest information on the epidemiology, clinical manifestations, diagnosis, pathogenesis, the impact of the diagnosis of celiac disease, and therapy, both current and future, of celiac disease. This program is AMA approved with 18.75 hours of Category 1 CME Credits™.

All events will take place at the Hilton NY Hotel unless noted otherwise. The Hilton NY Hotel is located at 1335 Avenue of the Americas (at 53rd Street & Sixth Avenue) New York, NY. All Food and Beverage served during the symposium will be gluten-free.

	Wednesday, November 8
	2:00 p.m. – 6:00 p.m.I	Registration Open 2nd Floor Promenade
	Thursday, November 9
	7:00 a.m. - 6:00 p.m.	Registration Open 2nd Floor Promenade
	7:00 a.m. - 9:00 a.m.	Breakfast buffet Rhinelander Gallery
	8:00 a.m. - 6:00 p.m.	Media Room Open Nassau Suite A
	8:00 a.m. - 6:00 p.m.	Press Conference Room Open Nassau Suite B
	8:00 a.m. - 6:30 p.m.	Exhibit Hall Open Rhinelander Gallery
	12:00 p.m. - 1:30 p.m.	Box Lunch Rhinelander Gallery
	12:00 p.m. - 1:30 p.m.	Poster Presentations Discovery Corridor, Rhinelander Gallery
	2:00 p.m. – 4:00 p.m.I	Session I What is Celiac Disease? Chairs Julio Bai, MD Dr. Carlos Bonorino Udaondo Gastroenterology Hospital Argentina Ricardo Troncone, MD University Federico II Italy Session Current Diagnostic Criteria for Celiac Disease: Need for a Revision? Julio Bai, MD Dr. Carlos Bonorino Udaondo Gastroenterology Hospital Argentina The Spectrum of Celiac Disease Ricardo Troncone, MD University Federico II Italy *Natural History of Celiac Disease* Katri Kaukinen, MD, PhD Tampere University Hospital Finland Intestinal mucosa anti-transglutaminase antibodies in early stage of gluten intolerance Fabiana Ziberna Early Epithelial Cell Alterations in “Latent/At Risk” Celiac Patients with Normal Histology Mala Setty Q&A Sutton Center, South & Regent Parlor
	4:00 p.m. – 4:20 p.m.	Break Rhinelander Gallery
	4:30 p.m. – 6:30 p.m.	Session II Impact of Diagnosis and Treatment of Celiac Disease Chairs Richard Logan, MB, ChB, MSc, MFPHM, FRCP Nottingham University UK Claes Hallert, MD, PhD Linköpings Universitet Sweden Session Should We Diagnose Everyone? Richard Logan, MB, ChB, MSc, MFPHM, FRCP Nottingham University UK Outcome of Untreated Celiac Disease Jacques Schmitz, MD Hopital Necker-Enfants Malades France Quality of Life Claes Hallert, MD, PhD Linköpings Universitet Sweden Complications: Malignancy and Fracture Risk Joe West, MD University of Nottingham UK The NIH Consensus Conference Stephen P. James, MD National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK) National Institutes of Health USA Physician Management of Positive Celiac Disease Screens Kelly McGowen, Decker Butzner Q&A Sutton Center, South & Regent Parlor
	7:00 p.m. – 10:00 p.m.	Gala Reception Amercan Museum of Natural History (Central Park West & 79th Street)

	Friday, November 10
	7:00 a.m. - 6:00 p.m.	Registration Open 2nd Floor Promenade
	7:00 a.m. - 9:00 a.m.	Breakfast Buffet Rhinelander Gallery
	8:00 a.m. - 6:00 p.m.	Media Room Open Nassau Suite A
	8:00 a.m. - 6:00 p.m.	Press Conference Room Open Nassau Suite B
	8:00 a.m. - 6:30 p.m.	Exhibit Hall Open Rhinelander Gallery
	8:30 a.m. – 12:00 p.m.	Session III Pathogenesis Chairs Ludvig Sollid, MD, PhD Rikshospitalet University Norway Marco Londei, MD University College, London UK Session Pathogenesis Overview Ludvig Sollid, MD, PhD Rikshospitalet University Norway Antigen Presenting Cells in the Gut Hans Christian Reinecker, MD Massachusetts General Hospital USA Antigen Presenting Cells in the Celiac Lesion Melinda Ráki, MD University of Oslo Norway Transferrin receptor mediates protected transcytosis of IgA/gliadin peptide complexes in active celiac disease Martine Heyman Transepithelial translocation of an alpha-gliadin 33mer Michael Schumann Q&A
	10:20 a.m. – 10:40 a.m.	Break Rhinelander Gallery
		Unexpected Role of Transglutaminase in Celiac Disease Marco Londei, MD University College, London UK Innate Immunity Bana Jabri, MD, PhD University of Chicago USA Gliadin P31-43 peptide can delay EGFR (Epidermal Growth Factor Receptor) decay interfering with the endocytic pathway Maria Vittoria Barone A transcriptome of tight junction genes in the normal and celiac disease-affected duodenal mucosa Cisca Wijmenga, Martin Wapenaar Q&A Sutton Center, South & Regent Parlor
	12:00 p.m. – 1:30 p.m.	Box Lunch Rhinelander Gallery
	12:00 p.m. – 1:30 p.m.	Poster Presentations Discovery Corridor, Rhinelander Gallery
	1:30 p.m. – 3:30 p.m.	Session IV New Tools for Investigating Celiac Disease Chairs Frits Koning, PhD Leiden University Medical Center Netherlands Detlef Schuppan, MD, PhD Beth Israel Deaconess Medical Center USA Session Evaluation and Manipulation of Grains Frits Koning, PhD Leiden University Medical Center Netherlands Intestinal Permeability Modulation Joerg D. Schulzke MD Charité-Universitätsmedizin Berlin Germany Genetic Predispositions for Celiac Disease Cisca Wijmenga, PhD University Medical Center Utrecht Germany Animal Models of Celiac Disease Joseph Murray, MD Mayo Clinic USA Wrap-Up Detlef Schuppan, MD, PhD Beth Israel Deaconess Medical Center USA Tetramer visualization of gut-homing gluten-specific T cells in the peripheral blood of celiac disease patients Melinda Raki Adaptive anti-gluten T cell immune response in HLA-DQ8/IL-15 Tg mice William DePaolo, Zara Hovhannisyan Q&A Sutton Center, South & Regent Parlor
	3:30 p.m. – 3:45 p.m.	Break
	4:00 p.m. – 6:00 p.m.	Session V Refractory Celiac Disease Chairs Chris Mulder, MD, PhD Vrije Universiteit Medical Center Netherlands Nadine Cerf-Bensussan, MD, PhD Necker Hospital France Session Definition and Therapy Chris Mulder, MD, PhD Vrije Universiteit Medical Center Netherlands Video Capsule and Double Balloon Endoscopy Christophe Cellier, MD, PhD Hospital Europeen Georges Pompidou France The Role of IL-15 in T Leukemogenesis and Lymphomagenesis Thomas A. Waldmann, MD NCI, National Institutes of Health USA Pathophysiology of Refractory Celiac Disease Nadine Cerf-Bensussan, MD, PhD Necker Hospital France Infliximab treatment of refractory celiac disease type I Knut Lundin Celiac Disease-Associated And Sporadic Small Bowel Neoplasia: Similarities And Differences Govind Bhaga
	7:00 p.m. – 10:00 p.m.	Celiac Soirée Hilton Grand Ballroom

	Saturday, November 11
	7:00 a.m. - 6:00 p.m.	Registration Open 2nd Floor Promenade
	7:00 a.m. - 9: 00 a.m.	Breakfast Buffet Rhinelander Gallery
	8:00 a.m. - 6:00 p.m.	Media Room Open Nassau Suite A
	8:00 a.m. - 6:00 p.m.	Press Conference Room Open Nassau Suite B
	8:00 a.m. - 6:30 p.m.	Exhibit Hall Open Rhinelander Gallery
	8:30 a.m. – 10:20 a.m.	Session VI Epidemiology of Celiac Disease Chairs Carlo Catassi, MD, MPH Universita di Ancona Italy Geoffrey Holmes, MD, PhD, FRCP Derbyshire Royal Infirmary UK Session Celiac Disease in Developing Countries Carlo Catassi, MD, MPH Universita di Ancona Italy Celiac Disease in Developed Countries Markku Mäki, MD, PhD University of Tampere Finland Natural History of Celiac Disease-Associated Antibodies Satu Simell The Swedish Epidemic of Celiac Disease Explored by Screening Anna Myleus Prevalence of celiac disease among the Japanese population Fumihiro Ishida Prevalence of coeliac disease in Tunisia: Mass screening study in school children Ben Hariz Mongi Q&A Sutton Senter, South & Regent Parlor
	10:20 a.m. – 10:40 a.m.	Break Rhinelander Gallery
	10:40 a.m. – 12:00 p.m.	Session VII Gluten Outside the Gut Chairs William Dickey, MD, PhD, FACG Altnagelvin Hospital Northern Ireland Norman Latov, MD, PhD Weill Medical College of Cornell University USA Session Changing Presentation of Celiac Disease William Dickey, MD, PhD, FACG Altnagelvin Hospital Northern Ireland Dermatitis Herpetiformis John J. Zone, MD University of Utah USA Neurological Manifestations Marios Hadjivassiliou, MB ChB, MRCP, MD, FRCP University of Sheffield UK Impact of Celiac Autoimmunity on Growth, Diabetes Control, and Bone Density of Subjects with Type 1 Diabetes Edward Hoffenberg Q&A Sutton Center, South & Regent Parlor
	12:00 p.m. - 12:30 p.m.	Innovation Award Ceremony Sutton Center, South & Regent Parlor Peter Green, MD, Celiac Disease Center at Columbia University
	12:30 p.m. – 1:20 p.m.	Box Lunch Rhinelander Gallery
	12:30 p.m. – 1:20 p.m.	Poster Presentations Discovery Corridor, Rhinelander Gallery
	1:30 p.m. – 3:30 p.m	Session VIII The Gluten-Free Diet Chairs Pekka Collin, MD, PhD, MPH Tempere University Hospital Finland Don Kasarda, PhD, (Retired) U.S. Department of Agriculture USA Session Keynote Address: Psychological Control Mechanisms Walter Mischel, PhD Columbia University USA Wheat, Oats and Other Cereals Pekka Collin, MD, PhD, MPH Tempere University Hospital Finland How Much Gluten is Too Much? Alessio Fasano, MD University of Maryland Medical Center USA The Measurement of Cereal Contamination in Gluten-Free Products Enrique Méndez Centro Nacional de Biotecnología Spain Compliance Issues Carolina Ciacci, MD Universita Federico II Italy The toxicity of HMW glutenins to patients with celiac disease Paul Ciclitra, Julia Ellis Gluten tolerance in celiac disease patients Maria Luisa Merarin Q&A Sutton Center, South & Regent Parlor
	3:30 p.m. – 3:45 p.m.	Break Rhinelander Gallery
	4:00 p.m. – 6:00 p.m.	Session IX Non-Dietary Therapies Chairs Chaitan Khosla, PhD Stanford University USA Robert Anderson, PhD, FRACP Walter & Eliza Hall Institute Australia Session New Chemical Entities for TG2 & DQ2 Inhibition Chaitan Khosla, PhD Stanford University USA Oral Enzyme Therapy Gary M. Gray, MD Stanford University USA Zonulin Receptor Antagonist AT1001 Blake Paterson, MD AlbaTherapeutics, USA Vaccines Robert Anderson, PhD, FRACP Walter & Eliza Hall Institute Australia Enzymatic degradation of gluten in a GI-tract model Cristina Mitea Q&A Sutton Center, South & Regent Parlor
	6:00 p.m. – 6:30 p.m.	Session X Closing Summary of Scientific Sessions Martin Kagnoff, MD University of California at San Diego USA Future Directions, Closing Remarks Peter Green, MD Celiac Disease Center at Columbia University USA Sutton Center, South & Regent Parlor

	Accreditation The College of Physicians and Surgeons of Columbia University is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians. The College of Physicians and Surgeons designates this educational activity for a maximum of 18.75 AMA PRA Category 1 Credits™. Physicians should only claim credit commensurate with the extent of their participation in the activity. This program has been planned and produced in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME). The American College of Nurse Practitioners (ACNP) and The American Academy of Physician Assistants (AAPA) accept AMA/PRA category 1 credit from organizations accredited by the ACCME. The American Nurses Credentialing Center (ANCC) accepts AMA/PRA category 1 credit toward recertification requirements. Disclosure The College of Physicians & Surgeons must ensure balance, independence, objectivity, and scientific rigor in its educational activities. All faculty participating in this activity are required to disclose to the audience any significant financial interest and/or other relationship with the manufacturer(s) of any commercial product(s) and/or provider(s) of commercial services discussed in his/her presentation and/or the commercial contributor(s) of this activity.